1 Synthesis and Antiproliferative Activity of 2 Diethylamine Mannich Base of Asymmetrical 3 Mono - Carbonyl Curcumin Analogs against HeLa 4 Cell Lines 5
نویسنده
چکیده
A series of diethylamine Mannich base of asymmetrical mono-carbonyl analogs of 10 curcumin (AMACs) were synthesized and evaluated for cytotoxic activity against Hela Cell lines. 11 The structures of the synthesized compounds were confirmed on the basis of FTIR, 1H-NMR, 12 13C-NMR and mass spectral data. Preliminary cytotoxic test using BSLT showed that all the 13 synthesized compounds exhibited more potent cytotoxic activity than that of curcumin. While 14 results of MTT assay showed that all the synthesized compounds exhibited more potent 15 antiproliferative activity against HeLa cell lines than that of cisplatin. Compound 2b exhibited as 16 the most potent compound of the series. Compound 2a, 2b, 2c, and 2f had IC50 (μM) less than that 17 of compound 1a, 1b, 1c and 1f indicating that the addition of diethylamine Mannich base improves 18 the antiproliferative activity of the parent compound. 19
منابع مشابه
Synthesis of kaempferide Mannich base derivatives and their antiproliferative activity on three human cancer cell lines.
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